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Harriet Knight is known for her contributions to literature and scholarship, particularly in the context of early modern writings. Her work often explores the intersection of philosophy and literature, providing insights into the intellectual climate of the time. Knight's research has shed light on important figures such as Francis Bacon and Robert Boyle, delving into their ideas and the influence they had on the development of scientific thought and natural philosophy.

Her notable publications include "The Oxford Francis Bacon I: Early Writings 1584-1596" which emphasizes Bacon's foundational role in the evolution of scientific methodology, and "Organising Natural Knowledge in the Seventeenth Century: The Works of Robert Boyle," which examines Boyle's contributions to the scientific revolution. Through her scholarly endeavors, Knight has established herself as a significant voice in the discourse surrounding early modern intellectual history.