A Study in Scarlet: Classics Illustrated No 110

This 1887 detective novel marks the first appearance of Sherlock Holmes and Dr Watson, who would become the most famous detective duo in literature. The book's title derives from a speech given by Holmes, a consulting detective, to his friend and chronicler Watson on the nature of his work, in which he describes the story's murder investigation as his “study in scarlet”. He also “There's the scarlet thread of murder running through the colourless skein of life, and our duty is to unravel it, and isolate it, and expose every inch of it.”